Micky van de Ven Brace Ends Everton's Run at Brand New Stadium
Micky van de Ven emerged as the first backline player to score twice in a English top-flight game for Tottenham since Jan Vertonghen in March 2013.
Match summary
The Spurs defender heads into the net twice in opening period
The home side's Jake O'Brien has equalizer disallowed after VAR review
Senegalese midfielder scores third in 89th minute
The defeat is Everton's initial at Hill Dickinson Stadium
The Tottenham defender found the net on two occasions as Spurs extended their unbeaten run on the road in the top division and delivered the Toffees their initial loss at their new home.
Everton were unbeaten in their five previous fixtures at their new ground at the dockside location, having left Goodison Park behind after 133 years at the conclusion of last season.
But Tottenham's leader the Dutchman struck twice from set-pieces in the opening 45 minutes to put their impressive record at jeopardy, and they were unable to mount a comeback before the midfielder - assisted by ex-Everton forward the Brazilian - nodded in a third to put the game to bed.
The Everton defender believed he had equalized the scores a short while after the defender's opener, glancing a bullet header past the Spurs keeper from an Everton corner.
Beto, in the meantime, failed to convert a number of opportunities, while the Italian goalkeeper made a series of excellent saves to guarantee the London club went five away games without defeat in the Premier League.
But the VAR intervened, instructing the match official to check the score on the pitchside monitor and the official ruled that the winger and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.
The win moves the manager's side up to third in the division, a handful of points off north London rivals and leaders Arsenal.
Everton stay in 14th position and are six points clear of the drop zone.
Tottenham analysis: Van de Ven excels in role at both ends of pitch
Following a drab weekday display in the Champions League against the French side, where they managed a mere two shots on target, the manager opted for Randal Kolo Muani up front instead of former Toffees player Richarlison.
The summer signing was unable to make much of an impact before being replaced for Richarlison after 60 minutes on the pitch, but it emerged he proved unnecessary in the final outcome.
Defender Van de Ven converted into an attacking force to be reckoned with.
Tottenham's opening strike came from a cleverly executed corner routine, with the midfielder heading the ball toward the six-yard box for an unmarked Van de Ven to score.
And Ven de Ven - filling in as skipper in the Argentine's absence - added his next goal in first-half stoppage time as he outjumped Jordan Pickford to nod in.
Van de Ven was equally outstanding in defence, combining effectively with Kevin Danso as the pair dealt excellently with the numerous deliveries sent their way by Everton.
Toffees breakdown: Toffees missing finishing touch
The club's recent stadium had been a happy hunting ground, but it seems the freshness may have worn off somewhat and supporters headed to the exits after the midfielder's final goal for Tottenham.
The end in Everton's unbeaten home run won't be a major worry for David Moyes, but their attacking woes will be.
The forward and Thierno Barry - the Everton's pair of established strikers - had scored just a single goal between them before Sunday's outing.
And they were unable to contribute to that miserable tally on a wet and gloomy evening on Merseyside.
Beto's performance was summed up when he chose to overhead kick a clear chance from close range, even with having room and opportunity to readjust for a more conventional attempt that would have tested Vicario.
The substitute, as well, was unable to influence the game after replacing the starter in the second half.
It wasn't for a lack of chance. Most of Everton's attacks came through the winger and the forward, who tirelessly delivered threatening balls into the Tottenham penalty area.
What next for these two sides?
The Toffees: The team travel to the Stadium of Light in the Premier League on early November at 20:00 GMT.
Spurs: The London club go to St James' Park on Wednesday, 29 October for their fourth-round League Cup tie against Newcastle.